Oakland, CA, is home to a large population of people struggling with poverty & substance abuse and has more than a hundred gangs. Although they are on a low budget, the ER at Highland Hospital will manage to treat a wide range of injuries and people.

A conscious man is wheeled into the ER with a two-inch pipe through his head. A young bride is experiencing unstoppable bleeding and her groom is clueless. Two prisoners from rival gangs are suspiciously in the ER at the same time.

A new doctor must stand up to a superior who wants to send his wife into surgery with undiagnosed rectal bleeding. A man comes into the ER with a surprising body part stuck inside a camping stove. And a six-year-old boy has a rare massive stroke.

While a shooting victim is brought to the hospital, a Rottweiler gets loose in the ER. A young mother’s asthma attack turns quickly into a deadly heart failure. A young man comes into the ER comatose, covered with a mysterious rash.

In Brazil, a man lives with a disability that left his head upside-down.

Four-year-old twins hope doctors can perform a surgery to separate them.

A man develops a huge mass on his chin after suffering from bone cancer.

An exhausted woman and a man with joint pain worry about their conditions.

An addicted woman finds it risky to go off methadone during pregnancy.

Losing their home, a pregnant couple lives in a tent and can't find work.

The trauma team treats a woman with a gunshot wound to her belly.

The trauma center sees victims of the bitter single-digit weather.

A teenager is unresponsive after a car crash.

A homemaker and energetic disc jockey experience bizarre occurrences.

A college student and a businesswoman experience bizarre occurrences.