Claudio, who has an upside down head, has become a motivational speaker.

Claudio has learned to live with his congenital arthrogryposis.

Trinny and her mother travel to London for treatment.

Trinny, an 8-year-old Ugandan girl, has a tumor on her face from fibrous dysplasia. She was asked to leave school because her appearance distracted the other students. Trinny and her mom travel to London in the hopes that a team of surgeons can help.

Gabriel was born without feet but that hasn't stopped him from playing sports. Soccer is his passion and his perserverance wins him a trip to Spain to meet his idol, Lionel Messi.

Amanda Grice is a 22-year-old with persistent genital arousal disorder (PGAD). Amanda explains her condition and the daily struggles of living with PGAD.

Shelly and Nick return to the hospital and learn a bit more about Nick's future with primordial dwarfism. Nick returns home and spends time with his brothers as they reflect on the uncertainty of his future.

In Nepal there are four sisters all suffering from osteogenesis imperfecta or brittle bone disease. They are unable to live independent lives and are finally getting much needed medical treatment.

Conjoined twins Jose Armando and Jose Luis share one digestive system and each has one leg but this doesn't stop them from living life to the fullest.

Los Angeles resident Lisa Johnson is bullied for the rare skin condition that she suffers from, but finds hope in various treatments.

Duangjay lives in rural Thailand. She was born with a rare case of macrodystrophia lipomatosa resulting in hands and arms that are too large for her body. In spite of her condition she is determined to live a normal life.

Diego was born in perfect health but as he aged he developed Parry-Romberg Syndrome which caused one side of his face to cave in.

Tere Lynn Russell and her three daughters have a genetic phenomenon that keeps their hair growing indefinitely. Tere's hair is 74" long.

A young girl whose face is covered in hair is used to standing out in a crowd.

The world's smallest woman does not let her height get in the way of her goals.

When a young girl is born with 8 limbs, members of her community think she’s the reincarnation of a goddess.