Claudio, who has an upside down head, has become a motivational speaker.

Claudio has learned to live with his congenital arthrogryposis.

Trinny and her mother travel to London for treatment.

Trinny, an 8-year-old Ugandan girl, has a tumor on her face from fibrous dysplasia. She was asked to leave school because her appearance distracted the other students. Trinny and her mom travel to London in the hopes that a team of surgeons can help.

Gabriel was born without feet but that hasn't stopped him from playing sports. Soccer is his passion and his perserverance wins him a trip to Spain to meet his idol, Lionel Messi.

Amanda Grice is a 22-year-old with persistent genital arousal disorder (PGAD). Amanda explains her condition and the daily struggles of living with PGAD.

Shelly and Nick return to the hospital and learn a bit more about Nick's future with primordial dwarfism. Nick returns home and spends time with his brothers as they reflect on the uncertainty of his future.

In Nepal there are four sisters all suffering from osteogenesis imperfecta or brittle bone disease. They are unable to live independent lives and are finally getting much needed medical treatment.

Conjoined twins Jose Armando and Jose Luis share one digestive system and each has one leg but this doesn't stop them from living life to the fullest.

Los Angeles resident Lisa Johnson is bullied for the rare skin condition that she suffers from, but finds hope in various treatments.

Duangjay lives in rural Thailand. She was born with a rare case of macrodystrophia lipomatosa resulting in hands and arms that are too large for her body. In spite of her condition she is determined to live a normal life.

Diego was born in perfect health but as he aged he developed Parry-Romberg Syndrome which caused one side of his face to cave in.

Tere Lynn Russell and her three daughters have a genetic phenomenon that keeps their hair growing indefinitely. Tere's hair is 74" long.

A young girl whose face is covered in hair is used to standing out in a crowd.

The world's smallest woman does not let her height get in the way of her goals.

When a young girl is born with 8 limbs, members of her community think she’s the reincarnation of a goddess.

Gabriel was born without feet but that hasn't stopped him from playing sports. Soccer is his passion and his perserverance wins him a trip to Spain to meet his idol, Lionel Messi.

Amanda Grice is a 22-year-old with persistent genital arousal disorder (PGAD). Amanda explains her condition and the daily struggles of living with PGAD.

Shelly and Nick return to the hospital and learn a bit more about Nick's future with primordial dwarfism. Nick returns home and spends time with his brothers as they reflect on the uncertainty of his future.

In Nepal there are four sisters all suffering from osteogenesis imperfecta or brittle bone disease. They are unable to live independent lives and are finally getting much needed medical treatment.

Conjoined twins Jose Armando and Jose Luis share one digestive system and each has one leg but this doesn't stop them from living life to the fullest.

Tere Lynn Russell and her three daughters have a genetic phenomenon that keeps their hair growing indefinitely. Tere's hair is 74" long.

A mystery illness makes the life of a housewife hell as her hearing becomes so acute the slightest noise is unbearably loud for her.

This DJ is at a loss when he continues to become drunk...despite the fact that he doesn't drink alcohol. This soon lands him in deep trouble.

Erika leads a normal life until one day she exhibits symptoms that appear to be demonic possession.

Shayna, a college student, finds her life on a downward spiral as she confronts a barrage of skin conditions with no explanation.

This DJ is at a loss when he continues to become drunk...despite the fact that he doesn't drink alcohol. This soon lands him in deep trouble, can he find the cause before his life falls apart?

When a hospital discovers that a baby has numerous fractures they immediately suspect the parents of child abuse and inform the police.

Doctors are at a loss when presented with a teenage girl who has extreme flu-like symptoms but her tests keep coming back normal.

A college student's life is thrown into hell when fingernail-like growths appear all over her body.

A 7-year old girl who loves ballet loses the use of her legs due to a mystery illness.

Troy has an insatiable appetite but even though he's overeating he's losing weight.