Claudio, who has an upside down head, has become a motivational speaker.
Claudio's Wishes Are Coming True
Claudio has learned to live with his congenital arthrogryposis.
Meet Claudio de Oliveira
Trinny and her mother travel to London for treatment.
Trinny's Fibrous Dysplasia
Trinny, an 8-year-old Ugandan girl, has a tumor on her face from fibrous dysplasia. She was asked to leave school because her appearance distracted the other students. Trinny and her mom travel to London in the hopes that a team of surgeons can help.
Young Girl Suffers from 4.4 LB Tumor on Her Face
Gabriel was born without feet but that hasn't stopped him from playing sports. Soccer is his passion and his perserverance wins him a trip to Spain to meet his idol, Lionel Messi.
Boy With No Feet is Also a Soccer Prodigy
Amanda Grice is a 22-year-old with persistent genital arousal disorder (PGAD). Amanda explains her condition and the daily struggles of living with PGAD.
Daily Life is Stressful for Woman with Persistent Orgasms
Shelly and Nick return to the hospital and learn a bit more about Nick's future with primordial dwarfism. Nick returns home and spends time with his brothers as they reflect on the uncertainty of his future.
In Nepal there are four sisters all suffering from osteogenesis imperfecta or brittle bone disease. They are unable to live independent lives and are finally getting much needed medical treatment.
Four Sisters Suffer from the Same Debilitating Bone Disorder
Conjoined twins Jose Armando and Jose Luis share one digestive system and each has one leg but this doesn't stop them from living life to the fullest.
Conjoined Twins with Very Different Personalities
Los Angeles resident Lisa Johnson is bullied for the rare skin condition that she suffers from, but finds hope in various treatments.
Skin Condition Leaves Woman with Two Skin Colors
Duangjay lives in rural Thailand. She was born with a rare case of macrodystrophia lipomatosa resulting in hands and arms that are too large for her body. In spite of her condition she is determined to live a normal life.
Thai Woman May Have the World's Largest Arms and Hands
Diego was born in perfect health but as he aged he developed Parry-Romberg Syndrome which caused one side of his face to cave in.
Young Boy's Face is Melting
Tere Lynn Russell and her three daughters have a genetic phenomenon that keeps their hair growing indefinitely. Tere's hair is 74" long.
A Family of Real-Life Rapunzels
A young girl whose face is covered in hair is used to standing out in a crowd.
Meet the Girl that Broke a Guinness World Record with her Disease
The world's smallest woman does not let her height get in the way of her goals.
When a young girl is born with 8 limbs, members of her community think she’s the reincarnation of a goddess.
The Girl with 8 Limbs