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Larina is a single mother and on the verge of losing custody of her 10-year-old daughter as a result of years of compulsive hoarding. But when confronted with the challenge to let go of her clutter, Larina's compulsion threatens to win the battle.

Joanne's hoarding is so extreme that the city has already sent her to jail four times. Also, Home buyers Tad and Amber purchased a family home sight unseen. Not until now do they realize that the house comes along with massive hoard.

Milton has always loved to shop. But after losing his mother, it became a compulsion that soon took over his life. Louise has been diagnosed with cancer and the unhealthy living conditions of her home are only making the reality of the prognosis worse.

Jason, 38, is a meth addict of 20 years whose addiction worsened after the sudden death of his father. No longer able to masquerade as a functional addict, Jason is now jobless, acutely in debt and in danger of losing his home in foreclosure.