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65-year-old Carole Battle suddenly finds herself struggling to walk in a straight line; On July 14, 1992, Sonya and Sherwood Webb welcome their second daughter, but they become alarmed when she begins to cry incessantly.

Doctors think baby Julie has a bad case of Chicken Pox, but no one can explain why she's getting worse with large blisters and a high fever. Then when Conor becomes a teenager, he starts to gain weight at an alarming rate.

Meredith Estes has baffling symptoms that can't be explained until she undergoes a risky left temporal craniotomy. Doug Posluszny can't explain his physical deterioration until an old acquaintance leads him to a physician who may have an answer.

Beth and Ryan Mantey's dream of a family finally comes true when Claire is born, but one look at their newborn and they can tell that something strange is going on. Will the Mantey's be able to solve the medical puzzle together before it's too late?