Doctors recount the most memorable cases they’ve ever encountered. Unusual, touching, humorous or life-changing – no story is too big or too small when it comes to the ER. The patients’ lives are hanging in the balance and it’s up to the doctors to save them.

Embark on a voyage of discovery unlike any other and uncover the real stories of individuals living with the most mysterious and incredible medical anomalies, and celebrate the remarkable spirit of the individuals who have persevered.

Careers and relationships are imperiled as the patients’ worsening ailments wreak havoc on their lives. Follow the incredible true stories of people struggling with baffling and life-threatening illnesses – and the brilliant doctors who diagnose them.

Go inside the homes of extreme hoarders to explore the psychology behind their compulsion to accumulate and store large quantities of nonessential things. Can they dig out of the mess into which they have gotten themselves?